Dr. Bing Yu

Dr. Bing YuMarquette University

Olin Engineering, 338C

MilwaukeeWI53201United States of America(414) 288-3251bing.yu@marquette.eduGoogle Scholar

Associate Professor

Joint Department of Biomedical Engineering

Director

Biophotonics Laboratory

Learn more about Biophotonics Lab

Professional Preparation

• Postdoctoral Associate, 2005–2008, Biomedical Engineering, Duke University
• Ph.D., 2005, Electrical and Computer Engineering, Virginia Tech
• M.S., 1994, Optoelectronics Technology, University of Electronic Science and Technology of China
• B.S., 1989, Optoelectronics Technology, University of Electronic Science and Technology of China

Courses Taught

BIEN 4320/5320 Biomedical Instrumentation Design—Fundamentals of solving instrumentation problems relating to biomedical and physiological measurements

BIEN 4520/5520 Introduction to Optics for Biomedical Engineers—An introduction to the fundamentals of optics and its applications in Biomedical Engineering 

BIEN 4931/5931/6931 Special Topics in BME—Optics

VIEW BIEN COURSE CATALOGUE

Research Interests

• Optical imaging and spectroscopy
• Optical endoscopy
• Cancer detection and therapeutic monitoring
• Miniature and cost-effective optical devices for global health

Selected Recent Publications

Tyrell To, Tongtong Lu, Julie M. Jorns, Mollie Patton, Taly Gilat-Schmidt, Tina Yen, Bing Yu, and Dong Hye Ye, “Deep Learning Classification of Deep Ultraviolet Fluorescence Images toward Intra-Operative Margin Assessment in Breast Cancer", Frontiers in Oncology 13, 1179025, 16 June 2023. doi: 10.3389/fonc.2023.1179025.

Tongtong Lu, Julie M. Jorns, Dong Hye Ye, Mollie Patton, Renee Fisher, Amanda Emmrich, Taly Gilat-Schmidt, Tina Yen, and Bing Yu, "Automated assessment of breast margins in deep ultraviolet fluorescence images using texture analysis," Biomedical Optics Express, Vol. 13, No. 8, 2022 08/01/2022, doi: 10.1364/BOE.464547.

S. Voulgarelis, F. Fathi, B.Yu, B. Palkovic, N.A. Chatzizacharias, K.P. Allen, A.G. Stucke, "Hepatic artery flow, inspired oxygen, and hemoglobin determine liver tissue saturation measured with visible diffuse reflectance spectroscopy (vis-DRS) in an in vivo swine model," Pediatr Transplant. 2022 Jan 22:e14230. doi: 10.1111/petr.14230. Epub ahead of print. PMID: 35064720.

S. Voulgarelis, F. Fathi, A.G. Stucke, K.D. Daley, J. Kim, M.A. Zimmerman, J.C. Hong, N. Starkey, K.P. Allen, B. Yu, "Evaluation of visible diffuse reflectance spectroscopy in liver tissue: validation of tissue saturations using extracorporeal circulation," J Biomed Opt. 26(5), 055002 (2021), doi: 10.1117/1.JBO.26.5.055002. PMID: 340215372021.

Tongtong Lu, Julie M. Jorns, Mollie Patton, Renee Fisher, Amanda Emmrich, Todd Doehring, Taly Gilat Schmidt, Dong Hye Ye, Tina Yen, Bing Yu, "Rapid assessment of breast tumor margins using deep ultraviolet fluorescence scanning microscopy," J. Biomed. Opt. 25(12), 126501 (2020), doi: 10.1117/1.JBO.25.12.126501. (Appeared on the cover page of the Journal).

Ullah, R.; Doerfer, K.; Khampang, P.; Fathi, F.; Hong, W.; Kerschner, J.E.; Yu, B., Real-Time Optical Monitoring of Endotracheal Tube Displacement. Biosensors 10(174), 2020.

VK Nagarajan, JM Ward, and B Yu, “Association of Liver Tissue Optical Properties and Thermal Damage,” Lasers in Surgery and Medicine, 09 January 2020.

Benej M, Hong X, Vibhute S, Scott S, Wu J, Graves E, Le QT, Koong AC, Giaccia AJ, Yu B, Chen CS, Papandreou I, Denko NC. Papaverine and its derivatives radiosensitize solid tumors by inhibiting mitochondrial metabolism. Proc Natl Acad Sci U S A. 2018 Oct 16;115(42):10756-10761. doi: 10.1073/pnas.1808945115. Epub 2018 Sep 10. Erratum in: Proc Natl Acad Sci U S A. 2018 Dec 4;115(49):E11561. PMID: 30201710; PMCID: PMC6196495.

Nagarajan VK, Gogineni VR, White SB, Yu B. Real time evaluation of tissue optical properties during thermal ablation of ex vivo liver tissues. Int J Hyperthermia. 2019 Jan 1;35(1):176-182. doi: 10.1080/02656736.2018.1488278. Epub 2018 Aug 21. PMID: 30130988.

P Edwards, C Zhang, B Zhang, X Hong, VK Nagarajan, B Yu, Z Liu, “Smartphone based optical
spectrometer for diffusive reflectance spectroscopic measurement of hemoglobin,” Scientific reports 7 (1), 12224, 2017.

Xiangqian Hong, Vivek K. Nagarajan, Dale H. Mugler and Bing Yu, “Smartphone microendoscopy for high resolution fluorescence imaging,” Journal of Innovative Optical Health Sciences, Vol.09, No. 05, 2016.

Vivek K. Nagarajan and Bing Yu, “Monitoring of tissue optical properties during thermal coagulation of ex vivo tissues,” Lasers Surg. Med., June 1, 2016. doi: 10.1002/lsm.22541.

Recent Grants

• Yu, Bing (Principal Investigator); Dong, Hye Ye; Gilat-Schmidt, Taly; Yen, Tina; Jorns, Julie; "Deep learning enabled, deep ultraviolet scanning microscopy for intraoperative assessment of margin status during breast cancer surgery." Sponsored by NIH (September 2022–May 2026).
• Yu, Bing (Principal Investigator); Lu, Tongtong; Dong, Hye Ye; Yen, Tina; Jorns, Julie; "Development of a deep-learning algorithm to enable deep-UV microscopy for intraoperative assessment of breast tumor margins." A preclinical pilot grant sponsored by the Medical College of Wisconsin Cancer Center (June 2022—May 2023).
• Yu, Bing (Principal Investigator); Kerschner, Joseph; Hong, Wenzhou; “Optical confirmation and monitoring of endotracheal tube position in pediatric patients.” Sponsored by NIH (April 2021–March 2023).
• Yu, Bing (Principal Investigator); “A Smartphone MicroEndoscope (Smart ME) for Cervical Cancer Screening in China.” Sponsored by Smart Biophotonics, LLC (January 2019–August 2024).
• Yu, Bing (Collaborator); Chen, Keke (Principal Investigator); Yu, Zeyun (Collaborator); "Adaptive Low-Cost Learning Machine Methods for Health Care Applications." Sponsored by Northwestern Mutual Data Science Institute.