Brian R. Hoffmann, Ph.D.

Brian Hoffman

Assistant Professor of Biomedical Engineering
Medical College of Wisconsin
(414) 955-7648
bhoffmann@mcw.edu
Complete CV
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Research interests

  • Understanding causative mechanisms leading to vascular impairment during type 2 diabetes
  • Analysis of the effects of protein glycosylation on cardiovascular disease and the onset/progression of diabetes
  • Utilization of high-throughput proteomic and genomic technologies for clinical disease applications
  • Characterization, isolation/separation, and functional analysis of extracellular vesicles

Professional preparation

Postdoctoral Fellowship, 2010-2014, Proteomics and Cardiovascular Physiology, Medical College of Wisconsin
Ph.D., 2010, Molecular and Cellular Pharmacology, University of Wisconsin-Madison
B.S., 2005, Biology (w/Chemistry Minor), Saint Norbert College

Selected recent publications

Neuner S, Wilmott L, Hoffmann BR, Mozhui K, and Kaczorowski CC.  Hippocampal proteomics defines pathways associated with memory decline and resilience in ‘normal’ aging and Alzheimer’s disease mouse models.  Behavioural Brain Research.  2016 June 2.  Pii: S0166-4328(16)30356-4. PMID 27265785. Doi: 10.1016/j.bbr.2016.06.002. [Epub ahead of print]

Prisco AR, Hoffmann BR, Kaczorowski CC, McDermott-Roe C, Stodola TJ, Exner EC, Greene AS TNFα Regulates Endothelial Progenitor Cell Migration via CADM1 and NF-kB. Stem Cells. 2016 Feb 11:

Karcher JR, Hoffmann BR, Liu P, Liu Y, Liang M, Greene AS Genome-wide epigenetic and proteomic analysis reveals altered Notch signaling in EPC dysfunction. Physiol Rep. 2015 Apr;3(4): PMCID: PMC4425964

Neuner SM, Wilmott LA, Hope KA, Hoffmann BR, Chong JA, Abramowitz J, Birnbaumer L, O'Connell KM, Tryba AK, Greene AS, Savio Chan C, Kaczorowski CC TRPC3 channels critically regulate hippocampal excitability and contextual fear memory. Behav Brain Res. 2015 Mar 15;281:69-77 PMCID: PMC4677051

Prisco AR, Bukowy JD, Hoffmann BR, Karcher JR, Exner EC, Greene AS Automated quantification reveals hyperglycemia inhibits endothelial angiogenic function. PLoS One. 2014;9(4):e94599 PMCID: PMC3981811

See More

Recent Grants

NIH NIDDK K01 (09/17/2015 - 07/31/2019)
Hoffmann, Brian R. (Principal); Greene, Andrew S (Mentor); Widlansky, Michael (Co-Mentor)
Evaluation of Endothelial Hyperglycemia-Driven Alteration During Type 2 Diabetes”, Sponsored by the National Institutes of Health, National Institute of Digestive, Diabetes and Kidney Disease.

NIH-NIDDK Clinical Research LRP (08/08/2016 - 07/31/2018)
Hoffmann, Brian R. (Principal)
Novel Therapeutic Pathways for Improved Vascular Function and Glycemic Control in Type 2 Diabetes”,Sponsored by the National Institutes of Health, National Institute of Digestive, Diabetes and Kidney Disease.

MAYO Metabolomics Resource Core Pilot Grant (07/01/2016-05/31/2017)
Hoffmann, Brian R. (Principal), Hessner, Martin (Co-Investigator),
The influence of sugar, artificial sweeteners, and the microbiome on metabolism”, Sponsored by the MAYO Metabolomics Resource Core Pilot Program supported by National Institutes of Health grant U24DK100469.

MCW Research Office Lupus Grant (07/01/2016 – 06/30/2017)
Rosenthal, Ann (Principal), Hoffmann, Brian R. (Co-Investigator)
“Defective clearance of apoptotic bodies in Systemic Lupus Erythematosus”, Sponsored by the Medical College of Wisconsin Research Office.

Cardiovascular Center/Advancing a Healthier Wisconsin Pilot Grant (07/01/2015 – 06/30/2016)
Hoffmann, Brian R. (Principal), Rosenthal, Ann (Co-Investigator), Kriegel, Alison (Co-Investigator)
“Microvesicles in Cardiovascular Inflammation”, Sponsored by the Medical College of Wisconsin Cardiovascular Center and Advancing a Healthier Wisconsin.

Students analyzing proteins

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Contact Us

If you have any questions or comments regarding the Marquette University and Medical College of Wisconsin Department of Biomedical Engineering, we are here to help!

bme@mcw.marquette.edu
(414) 288-3375 (for Marquette)
(414) 955-8671 (for MCW)

Mailing Address:
Olin Engineering Center
Room 206
1515 W. Wisconsin Avenue
Milwaukee, WI 53233