Professor of Biomedical Engineering
Cramer Hall 160, Marquette University
Zablocki VA Medical Center
Research Service 151
5000 W. National Ave.
Milwaukee, WI 53295
- Acute lung injury, Acute Respiratory Distress Syndrome (ARDS)
- Lung Transplantation
- Pulmonary endothelium metabolism, pulmonary hemodynamics
- Computational modeling
- Functional imaging (SPECT, optical)
Ph.D., 1993, Biomedical Engineering, Marquette University
M.S., 1990, Biomedical Engineering, Marquette University
B.S., 1988, Biomedical Engineering, Marquette University
Selected recent publications
Cui Ma, AM Beyer, M Durand, AV Clough, D Zhu, M Terashvili, JD Ebben, RB Hill, SH Audi, M Medhora, ER Jacobs, "Hyperoxia causes mitochondrial fragmentation in pulmonary endothelial cells by increasing expression of pro-fission proteins," Arterioscler Thromb Vasc Biol. 38: 00-00, 2018. DOI: 10.1161/ ATVBAHA.117.310605 (PMID: 29419407; NIHMSID 936375)
Ghanian, Z, GG Konduri, SH Audi, AKS Camara, and M Ranji, "Quantitative Optical Measurement of Mitochondrial Superoxide Dynamics in Pulmonary Artery Endothelial Cells," Journal of Innovative Optical Health Sciences 11(1), 2018. DOI: 10.1142/S1793545817500183 (NIHMSID 944772)
Audi, SH, ER Jacobs, X Zhang, AKS Camara, M Zhao, MM Medhora, B. Rizzo, AV Clough, "Protection by Inhaled Hydrogen Therapy in a Rat Model of Acute Lung Injury Can be Tracked in vivo Using Molecular Imaging," Shock: Injury, Inflammation, and Sepsis: Laboratory and Clinical Approaches 48(4):467-476, 2017. (PMID 28915216)
Densmore, J.C., T.R. Schaid, P.M. Jeziorczak, M. Medhora, S.H. Audi, J. Auchampach, S. Nayak, M.R. Dwinell, A. Geurts, and E.R. Jacobs, "Lung Injury Pathways: Adenosine Receptor 2B Signaling Limits Development of Ischemic Bronchiolitis Obliterans Organizing Pneumonia," Experimental Lung Research 43(1):38-48, 2017. (PMID 28266889)
Audi, S.H., A.V. Clough, S.T. Haworth, M. Medhora, M. Ranji, J.C. Densmore, E.R. Jacobs, "99mTcHexamethylpropyleneamine Oxime Imaging for Early Detection of Acute Lung Injury in Rats Exposed to Hyperoxia or Lipopolysaccharide Treatment," Shock: Injury, Inflammation, and Sepsis: Laboratory and Clinical Approaches 46(4):420-30, 2016. (PMID 26974426)
Audi, Said H (Principal), Clough, Anne V (Co-Principal), Jacobs, Elizabeth (Co-Principal), “SPECT Imaging and Computational Modeling for Assessment of Acute Lung Injury.” Sponsored by the NIH Heart, Lung, and Blood Institute. (July 1, 2015 - April 30, 2018).
Audi, Said H (Principal), Clough, Anne V (Co-Principal), "Novel imaging to identify lung mitochondrial injury and predict recovery," Sponsored by NIH Heart, Lung, and Blood Institute. (August 1, 2013 - April 30, 2018).
Audi, Said H (Principal), Clough, Anne V (Co-Principal), "Novel Diagnostics to Detect Lung Injury," Sponsored by Department of Veterans Affairs. (April 1, 2013 - March 31, 2018).
Audi, Said H (Principal), Clough, Anne V (Co-Principal), "Research for preclinical evaluation of a novel treatment for acute lung injury." Sponsored by The Alvin and Marion Birnschein Foundation. (January 1, 2014 - December 30, 2017).