The Biomaterials & Histology Laboratory’s most recent manuscript was accepted for publication by the European Spine Journal, a journal devoted to spine-related disciplines, including functional and surgical anatomy of the spine, biomechanics, pathophysiology, diagnostic procedures, neurology and surgical outcomes.
The accepted publication, “A Comparison of Inflammatory Host Response to Particulate Debris Adjacent to Unlocked and Locked Screws of a Growth Guidance System for Early Onset Scoliosis”, discusses the potential inflammatory response to particulate debris of an implanted stainless-steel rod and screw system commonly used to stabilize the spine during growth in patients with early onset scoliosis.
The publication was co-authored by Dr. Jeffrey Toth, Director and Principal Investigator of OREC’s Biomaterials & Histology (BIMA) Laboratory, and Dr. Felix Ankomah, an Orthopaedic Surgery resident from the Medical College of Wisconsin, who collaborates with BIMA on research involving explant analysis of and tissue response to pediatric spinal growth guidance systems.
For this investigation, the OREC's BIMA Laboratory performed the gross, radiographic, and histologic analysis in tissues adjacent to the SHILLA Growth Guidance System devices, as well as the histologic grading/scoring for inflammation by ISO 10993, part 6, in tissues adjacent to the devices. Dr. Ankomah assisted with the histologic scoring schema and write-up as part of his research requirements as a resident. Dr. Ankomah also presented the paper at the Orthopaedic Research Society Meeting held in February of 2022 in Tampa, Florida.
Toth JM, Ankomah F, Kawakami N, Uno K: A Comparison of the Inflammatory Host Response to Particulate Debris Adjacent to Unlocked and Locked Screws of a Growth Guidance System for Early Onset Scoliosis. European Spine Journal, DOI 10.1007/s00586-022-07271-2
