September 2021
BIMA’s recent manuscript, “Biological Resurfacing in a Canine Model of Hip Osteoarthritis," was accepted for publication by Science Advances, a peer-reviewed, multidisciplinary, open-access scientific journal with an impact factor of 14.136 (2020). Co-authored by members of MCW’s Department of Orthopaedic Surgery, including Drs. Jeffrey Toth and Peter Eggert, an orthopaedic surgery resident, the article details a recent study exploring the viability of bicomponent implants as a potential therapy for moderate hip osteoarthritis. The biocomponent implant explored is a 3-D printed, woven polycaprolactone (resorbable polymer) device seeded with mesenchymal stem cells designed to effect cartilage repair and bone ingrowth in osteochondral defects, a validated canine model of osteoarthritis.
The manuscript resulted from National Institutes of Health (NIH) award R42AR055042-SA02 and the MCW Department of Orthopaedic Surgery. Research discussed includes undecalcified and decalcified histology through the Tissue Engineering Implant, which was performed by BIMA, as well as histological evaluation/grading, shown in figure 5 of the article. Dr. Peter Eggert performed the O’Driscoll scoring schema for osteochondral defect repair as part of his research requirements as a resident. Primary authors include Dr. Farshid Guilak from Washington University in St. Louis and Dr. Brad Estes at Cytex Therapeutics.
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