NIGIL Research

Research at the Nanomedicine and Image-guided Interventions Laboratory at the Marquette University and Medical College of Wisconsin Joint Department of Biomedical Engineering seeks to develop minimally invasive and non-toxic diagnostic and therapeutic technologies directed to cancer, pulmonary and infectious disease, and other vascular pathologies. 


Current Projects

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Genetic Mapping of Breast Cancer Risk in the Tumor Microenvironment

Investigators at NIGIL are looking to develop and utilize the novel Consomic Xenograft Model for elucidating germline variants that impact breast cancer risk through the tumor microenvironment.

Inforgraphic describing genetic mapping of breast cancer risk

Joshi, Amit (Principal Investigator). "Genetic Mapping of Breast Cancer Risk in the Tumor Microenvironment." Sponsored by the National Cancer Institute, NIH 5R01CA193343–05 (April 2015–March 2021).


Developing Novel Trans-tympanic Drug-delivery Formulas to Treat Otitis Media

Drug-delivery graphicThis project seeks to develop nanoparticle formulations of antibiotic and/or steroid drugs for treating otitis media via external ear application.

Joshi, Amit (Principal Investigator).  "Develop Novel Trans-tympanic Drug-delivery Formulas to Treat Otitis Media." Sponsored by NIH Allergy and Infectious Disease, NIH-R21AI 147607-01 (July 2019–June 2021).


Mechanism of Radiation-induced Vascular Injury in Normal Tissue

Radiation Distribution MapThe Radiation-induced Vascular Injury project seeks to study the mechanisms and determine optical and MR image-based early biomarkers for radiation-induced vascular injury.

Joshi, Amit (Co-investigator); Medhora, Meetha (Principal Investigator).  "Mechanism of radiation-induced vascular injury in normal tissue:  role of the Notch-D114 pathway."   Sponsored by NIH Allergy and Infectious Disease, NIH-1U01A1 133594-01 (December 2017–July 2022).


Roles of Nogo-B receptor in Maintaining the Structural Integrity of Blood Vessels

PCA Merge of Rodent BrainInvestigators at NIGIL are studying the role of Nogo-B expression on the development of intracranial blood vessels. Shortwave-IR emitting quantum dots will be utilized for imaging intracranial hemorrhage.

Joshi, Amit (Co-investigator); Miao, Q. (Principal Investigator). "Roles of Nogo-B receptor in maintaining the structural integrity of blood vessels." Sponsored by the NIH, National Heart Lung and Blood Institute; NIH-1R01HL141733-01 (April 2018–March 2023).



Radiation-induced Modulation of TGF Beta Signaling: Part 2

The Radiation-induced Modulation of TGF Beta Signaling project, Part 2, looks to study the mechanisms of radiation-induced vascular injury and determine image-based biomarkers for the same.

Amit, Joshi (Co-investigator); Medhora, Meetha (Principal Investigator). "Radiation-induced Modulation of TGF Beta Signaling: Part 2."  Sponsored by Innovation Pathways HHSN272201800012C (April 2018–March 2023). 




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