Biophotonics Publications

Journal PublicationsBook Chapters 

Journal Publications

Tyrell To, Tongtong Lu, Julie M. Jorns, Mollie Patton, Taly Gilat-Schmidt, Tina Yen, Bing Yu, and Dong Hye Ye, “Deep Learning Classification of Deep Ultraviolet Fluorescence Images toward Intra-Operative Margin Assessment in Breast Cancer", Frontiers in Oncology 13, 1179025, 16 June 2023. doi: 10.3389/fonc.2023.1179025.

Tongtong Lu, Julie M. Jorns, Dong Hye Ye, Mollie Patton, Renee Fisher, Amanda Emmrich, Taly Gilat-Schmidt, Tina Yen, and Bing Yu, "Automated assessment of breast margins in deep ultraviolet fluorescence images using texture analysis," Biomedical Optics Express, Vol. 13, No. 8, 2022 08/01/2022, doi: 10.1364/BOE.464547.

Luo, T., Lu, T., Yu, B., and Tina W.F. Yen, "Recent Advances in Intraoperative Lumpectomy Margin Assessment for Breast Cancer". Curr Breast Cancer Rep 2022. doi: 10.1007/s12609-022-00451-5

S. Voulgarelis, F. Fathi, B.Yu, B. Palkovic, N.A. Chatzizacharias, K.P. Allen, A.G. Stucke, "Hepatic artery flow, inspired oxygen, and hemoglobin determine liver tissue saturation measured with visible diffuse reflectance spectroscopy (vis-DRS) in an in vivo swine model," Pediatr Transplant. 2022 Jan 22:e14230. doi: 10.1111/petr.14230. Epub ahead of print. PMID: 35064720.

S. Voulgarelis, F. Fathi, A.G. Stucke, K.D. Daley, J. Kim, M.A. Zimmerman, J.C. Hong, N. Starkey, K.P. Allen, B. Yu, "Evaluation of visible diffuse reflectance spectroscopy in liver tissue: validation of tissue saturations using extracorporeal circulation," J Biomed Opt. 26(5), 055002 (2021), doi: 10.1117/1.JBO.26.5.055002. PMID: 340215372021.

Tongtong Lu, Julie M. Jorns, Mollie Patton, Renee Fisher, Amanda Emmrich, Todd Doehring, Taly Gilat Schmidt, Dong Hye Ye, Tina Yen, Bing Yu, "Rapid assessment of breast tumor margins using deep ultraviolet fluorescence scanning microscopy," J. Biomed. Opt. 25(12), 126501 (2020), doi: 10.1117/1.JBO.25.12.126501. (Appeared on the cover page of the journal)

Ullah, R.; Doerfer, K.; Khampang, P.; Fathi, F.; Hong, W.; Kerschner, J.E.; Yu, B., Real-Time Optical Monitoring of Endotracheal Tube DisplacementBiosensors 10(174), 2020.

VK Nagarajan, JM Ward, and B Yu, “Association of Liver Tissue Optical Properties and Thermal Damage,” Lasers in Surgery and Medicine, 09 January 2020.

Hong, X., Lu, T., Fruzyna, L. et al. "A Dual-modality Smartphone Microendoscope for Quantifying the Physiological and Morphological Properties of Epithelial Tissues," Sci Rep 9, 15713 (2019) doi:10.1038/s41598-019-52327-x.

Benej M, Hong X, Vibhute S, Scott S, Wu J, Graves E, Le QT, Koong AC, Giaccia AJ, Yu B, Chen CS, Papandreou I, Denko NC. Papaverine and its derivatives radiosensitize solid tumors by inhibiting mitochondrial metabolism. Proc Natl Acad Sci U S A. 2018 Oct 16;115(42):10756-10761. doi: 10.1073/pnas.1808945115. Epub 2018 Sep 10. Erratum in: Proc Natl Acad Sci U S A. 2018 Dec 4;115(49):E11561. PMID: 30201710; PMCID: PMC6196495.

Nagarajan VK, Gogineni VR, White SB, Yu B. Real time evaluation of tissue optical properties during thermal ablation of ex vivo liver tissues. Int J Hyperthermia. 2019 Jan 1;35(1):176-182. doi: 10.1080/02656736.2018.1488278. Epub 2018 Aug 21. PMID: 30130988.

P Edwards, C Zhang, B Zhang, X Hong, VK Nagarajan, B Yu, Z Liu, “Smartphone based optical
spectrometer for diffusive reflectance spectroscopic measurement of hemoglobin,” Scientific Reports 7 (1), 12224, 2017.

Martin Benej, Ioanna Papandreou, Xiangqian Hong, Bing Yu, Nicholas Denko, "Hypoxic tumors can be sensitized to radiation therapy by repurposing papaverine as an inhibitor of mitochondrial respiration," Cancer Research 77 (13 Supplement), 5841-5841.

Xiangqian Hong,Vivek K. Nagarajan, Dale H. Mugler and Bing Yu, “Smartphone microendoscopy for high resolution fluorescence imaging,” Journal of Innovative Optical Health Sciences, 09, No. 05, 2016.

Vivek K. Nagarajan and Bing Yu, “Monitoring of tissue optical properties during thermal coagulation of ex vivo tissues,” Lasers Surg. Med., June 1, 2016. doi: 10.1002/lsm.22541.

Bing Yu, Daron G. Ferris, Yang Liu and Vivek K. Nagarajan, “Emerging Optical Techniques for Detection of Oral, Cervical and Anal Cancer in Low-Resource Settings," Austin Journal of Biomedical Engineering, Vol. 1, Iss. 2:15, 2014. (Invited review article).

Bing Yu, Amy Shah, Vivek K. Nagarajan, and Daron G. Ferris, “Diffuse reflectance spectroscopy of epithelial tissue with a smart fiber-optic probe,” Biomedical Optics Express Vol. 5, Iss. 3, pp. 675–689 (2014)

Bing Yu, Amy Shah, Bingqing Wang, Narasimhan Rajaram, Quanli Wang, Nirmala Ramanujam, Gregory M. Palmer, and Mark W. Dewhirst, “Measuring Tumor Cycling Hypoxia and Angiogenesis using a Side-firing Fiber Optic Probe,” Journal of Biophotonics, Vol. 7, Iss. 7, pages 552–564 (2014), doi: 10.1002/jbio.201200187.

Justin Y. Lo, J. Quincy Brown, Sulochana Dhar, Bing Yu, Gregory M. Palmer, Nan M. Jokerst, and Nirmala Ramanujam, “Wavelength optimization for quantitative spectroscopic imaging of breast tumor margins,” PLoS ONE 8(4): e61767. doi:10.1371/journal.pone.0061767 (2013).

Sulochana Dhar, Justin Y. Lo, Greg Palmer, Martin A. Brooke, Brandon Nichols, Bing Yu, Nimmi Ramanujam, and Nan M. Jokerst, “A Diffuse Reflectance Spectral Imaging System for Tumor Margin Assessment Using Custom Annular Photodiode Arrays,” Biomedical Optics Express, Vol. 3, Iss. 12, pp. 3211–3222 (2012).

Vivide T.C. Chang, Delson Merisier, Bing Yu, David K. Walmer,and Nirmala Ramanujam, “Towards a field-compatible optical Spectroscopic device for cervical cancer screening in resource-limited settings: effects of calibration and pressure,” Optics Express, Vol. 19, Iss. 19, pp. 17908–17924 (2011).

B. Yu, H.L. Fu and N. Ramanujam, “Instrument-Independent Diffuse Reflectance Spectroscopy,” Journal of Biomedical Optics, Vol. 16(1): p. 011010 (2011).

H.L. Fu, B. Yu, J.Y. Lo, G.M. Palmer, T.F. Keuch, and N. Ramanujam, “A low-cost, portable, and quantitative spectral imaging system for application to biological tissues,” Optics Express, Vol. 18, Iss. 12, pp. 12630–12645 (2010).

J.Q. Brown, T.M. Bydlon, L.M. Richards, B. Yu, S.A. Kennedy, J. Geradts, L.G. Wilke, M. Junker, J. Gallagher, W. Barry, and N. Ramanujam, “Optical assessment of tumor resection margins in the breast,” Journal of Selected Topics in Quantum Electronics, Vol. 16(3), pp. 530–544, 2010.

T.M. Bydlon, S.A. Kennedy, L.M. Richards, J.Q. Brown, B. Yu, M.S. Junker, J. Gallagher, J. Geradts, L.G. Wilke, and N. Ramanujam, “Performance metrics of an optical spectral imaging system for intra-operative assessment of breast tumor margins”. Optics Express, Vol. 18, Iss. 8, pp. 8058-8076 (2010).

J.E. Bender, A.B. Shang, E.W. Moretti,B. Yu,L.M. Richards and N. Ramanujam, “Noninvasive monitoring of tissue hemoglobin using UV-VIS diffuse reflectance spectroscopy: a pilot study,” Optics Express, Vol. 17, Iss. 26, pp. 23396-23409 (2009).

C. Zhu, E.S. Burnside, G.A. Sisney, L.R. Salkowski, J.M. Harter, B. Yu and N. Ramanujam, “Fluorescence spectroscopy: an adjunct diagnostic tool to image-guided core needle biopsy of the breast,” IEEE Trans Biomed Eng. 2009 Oct;56(10):2518–28.

J.Y. Lo, B. Yu, H.L. Fu, J.E. Bender, G.M. Palmer, T.F. Kuech and N. Ramanujam, “A strategy for quantitative spectral imaging of tissue absorption and scattering using light emitting diodes and photodiodes,” Optics Express. 17 (3):1372–1384, 2009.

B. Yu, J.Y. Lo, T.F. Kuech, G.M. Palmer, J.E. Bender, N. Ramanujam, “A Cost-Effective Diffuse Reflectance Spectroscopy Device for Quantifying Tissue Absorption and Scattering In Vivo,” Journal of Biomedical Optics, Vol. 13, No. 6, 2008.

B. Yu, H.L. Fu, T.M. Bydlon, J.E. Bender and N. Ramanujam, “Diffuse reflectance spectroscopy with a self-calibrating fiber optic probe,” Optics Letters, Vol. 33, Iss. 16, pp. 1783–1785 (2008).

B. Yu, E.S. Burnside, G.A. Sisney, J.M. Harter, C. Zhu, A.H. Dhalla and N Ramanujam, “Feasibility of near-infrared diffuse optical spectroscopy on patients undergoing image-guided core-needle biopsy,” Optics Express 15, pp. 7335–50 (2007).

B. Yu, A. Wang, and G.R. Pickrell, “Analysis of Fiber Fabry-Perot Interferometric Sensors Using Low-Coherence Light Sources,” Journal of Lightwave Technology, Vol. 24, No. 4. pp. 1758–67 (2006).

B. Yu, A. Wang, G.R. Pickrell, and J. Xu, “Tunable Optical Filter Based White Light Interferometry for Sensing,” Optics Letters, Vol. 30, No. 12, pp.1452–54 (2005).

B. Yu, G.R. Pickrell, and A. Wang, “Thermally Tunable Extrinsic Fabry-Perot Filter,” IEEE Photonics Technology Letters, Vol. 16, No. 10, pp. 2296–98 (2004).

B. Yu and A. Wang, “Grating-assisted Demodulation of Interferometric Optical Sensors”, Applied Optics, Vol. 42, No. 34, pp. 6824–29 (2003).

B. Yu, D.-W. Kim, J. Deng, H. Xiao, and A. Wang, “Fiber Fabry-Perot sensors for detection of partial discharges in power transformers”, Applied Optics, Vol.42, No.16, pp. 3241–50 (2003).

B. Yu and B. Cai, “The Application Techniques of WDM in Optical SDH Communication Systems,” Optical Communication Technology, Vol. 24, No. 86, pp.13–18, (2000) (in Chinese).


Book Chapters

"Bing Yu, Daron G. Ferris, and Vivek Krishna Nagarajan, "Mobile Fiber-optic Sensor for Detection of Oral and Cervical Cancer in Developing World", in Mobile Health Technologies - Methods and Protocols, Editors Avraham Rasooly and Keith E. Harold, Humana Press, 2015."

"Bing Yu and Nirmala Rmanujam, "Quantitative Diffuse Reflectance Imaging of Tumor Margins", Chapter 17 in Biomedical Photonics Handbook, Editor-in-Chief Tuan Vo-Dinh, 2nd Edition, CRC Press, 2015."

"Bing Yu, "Servo System of a Magneto-optical Disk Driver," Chapter 2 of Part II in Magneto-opitcal Recording Technology, UESTC Publisher, pp146–176, 1994 (in Chinese)."