Research Overview | Ongoing Projects
Research in the Computational Systems Biology Laboratory utilizes mathematical and computational modeling and experimental measurements at multiple levels of biological complexity to inform, refine, and uncover a mechanistic understanding of a variety of biological systems. Much of this work is on the integrated physiology of solute transport and energy metabolism in tissue/organ systems, with a major focus on skeletal muscle, heart, and kidney cellular metabolism and energetics under normal and pathological conditions such as hypoxia, ischemia, exercise, diabetes, and hypertension. These studies involve the development of multi-scale computational models encompassing molecular, subcellular, cellular, and tissue/organ processes and mechanisms, along with numerical methods and algorithms for model parameter optimization to experimental data, which is an important task in gaining mechanistic understandings of these biological systems. Such studies are crucial for quantitative understanding of the mechanisms of metabolic regulation in tissue/organ systems in vivo, including control of mitochondrial oxygen consumption (respiration), substrate and energy metabolism, and ATP homeostasis under different conditions. Such studies are also critical for understanding disease pathology and progression, specifically how subcellular events causing disturbances or malfunction at the cellular level are translated to affect whole-organ function causing disease.
The Computational Systems Biology Laboratory is looking for researchers with an interest in metabolic systems and computational modeling. For further information on becoming the next addition to the CSBL, contact Dr. Ranjan Dash.
