CLPL Research

The research methodology at the Computational Lung Physiology Laboratory (CLPL) includes the use of optical and molecular imaging, in combination with computational modeling, for mechanistic interpretation of experimental data and the use of genetically modified rodents and other animal models of human lung disease.   

 

Current Projects 

Learn more about projects currently underway in the Computational Lung Physiology Laboratory at the Marquette University and Medical College of Wisconsin Department of Biomedical Engineering.

 

Imaging Lung Injury & Disease

The principal investigators at the CLPL have pioneered the use of imaging novel biomarkers as a means of early detection and monitoring of mechanisms and pathways involved in lung injury and disease.  

Learn more about Imaging Lung Injury & Disease

 

Imaging Cellular Function in Lung Tissue

The CLPL is using molecular fluorescence imaging to probe cellular function in lung cells and tissue. This approach has the potential to provide a quantitative assessment of the effect of injurious conditions on lung mitochondrial function and to evaluate the impact of therapies that target mitochondria.

Learn more about Imaging Cellular Function in Lung Tissue

 

Computational Modeling of Lung Bioenergetics

To assist with interpreting the complex processes of lung function, the CLPL is using computational modeling as a framework for integrating bioenergetic data at different levels of biological organization.

Learn more about Computational Modeling of Lung Bioenergetics

 

Mitochondrial Dysfunction in Lung Injury

The CLPL is investigating the molecular basis of hyperoxia-associated mitochondrial-fragmentation in pulmonary endothelial cells and subsequent pulmonary microvascular permeability, complications commonly associated with mechanical ventilation.

Learn more about Mitochondrial Dysfunction in Lung Injury