Pediatric Activity Risk Assessment

Study of push off in osteogenesis imperfectaOsteogenesis Imperfecta (OI) is a genetic disorder resulting in bone fragility and, often, deformation of the long bones. Children with OI are at an increased risk of fracture due to the altered mechanical and material properties of their bones. Finite element (FE) modeling and analysis is a quantitative tool for assessing an object’s response to loading and if/when that object may fail/break. OREC investigators have used this methodology to assess patient-specific fracture risk of the femur in children with OI. The model has been refined over the years to include the most updated techniques and OI material property data.

Image:  Study of push-off in osteogenesis imperfecta, type I, with (Left) reduced ankle range of motion and plantarflexion during third rocker and (Right) greater ankle power absorption during terminal stance and reduced ankle power generation during push off.

Selected Publications

Fritz JM, Guan Y, Wang M, Smith PA, and Harris GF: A Fracture Risk Assessment Model of the Femur in Children with Osteogenesis Imperfecta (OI) During Gait, Medical Engineering & Physics, 31:1043- 1048.

Fritz JM, Smith PA and Harris GF: A Finite Element Fracture Risk Assessment Model of the Femur During Gait in Children with Osteogenesis Imperfecta, Biomedical Sciences Instrumentation, 45:316-321.

Grover, P. and Harris, G.: NIH Visible Human Project Humerus Numerical and Physical Models: Characterization for Osteogenesis Imperfecta Study. Transitional Care in OI: Advances in Biology, Technology and Clinical Practice, Eds.: Smith, P., Rausch, F. and Harris, G., Shriners Press, Chicago, Chapter 10, 161-176.

Garman, C., Krzak, J., Caudill, A., Graf, A., Smith, P., Harris, G.: Gait Deviations in Children with Osteogenesis Imperfecta Type I. Journal of Pediatric Orthopaedics (JPO). 98 (10), 39(8):e641-e646.

Fritz, J.M., Grosland, N.M., Smith, P.A., Harris, G.F.: A Geometry Sensitivity in Finite Element Models of Long Bones in Osteogenesis Imperfecta. Biomed Sci Instrum, 55:2, 349-353, 2019.

Murali, C.N., Cuthbertson, D., Slater, B., Nguyen, D., Turner, A., Harris, G., Sutton, V.R., Lee, B., Nagamani and Members of the BBD Consortium: Pediatric Outcomes Data Collection Instrument is a Useful Patient-Reported Outcome Measure for Physical Function in Children with Osteogenesis Imperfecta, Genetics in Medicine [In Press, 2020].



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