Dr. Yi Hong is a Distinguished Research Professor in the Bioengineering Department at the University of Texas at Arlington (UTA). His research focuses on developing functional and bioactive soft biomaterials and translational research for tissue repair and regeneration applications, especially for cardiovascular disease treatment, and women and children healthcare. He has published over 120 peer-review papers in the field of biomaterials and applied/issued 14 patents as well as over 180 conference abstracts. He received many awards, such as NSF CAREER award, University’s Outstanding Research Award, AHA Established Investigator Award, and COE Award for Distinguished Record of Research. He is an elected Fellow of AHA, AIMBE, RSC, and BMES and a Senior Member of National Academy of Inventors.
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Abstract: Engineering Biological Materials for Cardiac Engineering
Biomaterials have been broadly utilized for varieties of biomedical applications, including cell culture, tissue models, medical devices, and tissue repair and regeneration. Seeking a suitable biomaterial for soft tissue repair is complex and significant. The biomaterial properties are expected to be biosafe and mimetic to the native tissue, such as structure, mechanics and biofunctions. The decellularized extracellular matrix (ECM) materials, including heart ECM, have been used in biomedical engineering, clinic trials and clinic, because of their good biocompatibility and bioactivity and unique specific complex components mimicking the target tissues. Our group has been working on decellularized cardiac ECM materials for many years, focusing on applications in cardiac cell culture and myocardial repair. In this talk, I will introduce our works on utilizing cardiac ECM material to modify the synthetic biomaterials, enable localized drug release, and develop new material formulations for cardiac engineering, which would provide inspirations to broaden its new applications to address the fundamental questions and clinic challenges.