Virtual surgery planning based on computational fluid dynamics (CFD) to improve surgical outcomes for nasal airway obstruction
Fluid-structure interaction (FSI) simulations of upper airway collapse in obstructive sleep apnea
Respiratory drug delivery, including the application of CFD models to improve the design of nasal sprays for chronic rhinosinusitis
Regulation of airway surface liquid (ASL) hydration, including mathematical models of ion transport and ASL dehydration in cystic fibrosis (CF) epithelia
Recent Publications
Recent Grants
Guilherme Garcia (Principal Investigator), John Rhee (Co-Investigator), Tucker Woodson (Co-Investigator),“Determining the phenotype of airway collapse in obstructive sleep apnea”. Sponsored by the Advancing a Healthier Wisconsin Endowment. (January 1, 2019–December 31, 2020)
Andinet Enquobahrie (Principal Investigator, Kitware Inc.), John Rhee (Co-Investigator, MCW), Guilherme Garcia (Co-Investigator), and other collaborators, “An Interactive, Patient-Specific Virtual Surgical Planning System for Upper Airway Obstruction Treatments” (R44 EB023121). Sponsored by the National Institute of Biomedical Imaging and Bioengineering (NIBIB). (September 23, 2019–September 22, 2020)
Jeffry Schroeter (Principal Investigator, Applied Research Associates, Inc.), William Bennett (Co-Investigator, University of North Carolina at Chapel Hill), Julia Kimbell (Co-Investigator, University of North Carolina at Chapel Hill), Guilherme Garcia (Co-Investigator), and other collaborators, “Modifications and Improvements to Hybrid CFD-PBPK Models for Predictions of Nasal Corticosteroid Deposition, Absorption and Bioavailability" (BAA-PMQWP#220). Sponsored by the U.S. Food & Drug Administration (FDA). (July 1, 2020–September 30, 2022)
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