Dr. Bing Yu
Dr. Bing YuMarquette University

Olin Engineering, 338C

MilwaukeeWI53201United States of America
(414) 288-3251
Curriculum Vitae

Associate Professor

Joint Department of Biomedical Engineering


Biophotonics Laboratory

Professional Preparation

  • Postdoctoral Associate, 2005–2008, Biomedical Engineering, Duke University
  • Ph.D., 2005, Electrical and Computer Engineering, Virginia Tech
  • M.S., 1994, Optoelectronics Technology, University of Electronic Science and Technology of China
  • B.S., 1989, Optoelectronics Technology, University of Electronic Science and Technology of China

Courses Taught

BIEN 4320/5320 Biomedical Instrumentation Design—Fundamentals of solving instrumentation problems relating to biomedical and physiological measurements

BIEN 4931/5931/6931 Special Topics in BME—Optics

BIEN 5500 Medical Imaging Physics—Examines how light, X-rays, radiopharmaceuticals, ultrasound, magnetic fields, and other energy probes are generated and how they interact with tissues and detectors to produce useful image contrast




Research Interests

  • Optical imaging and spectroscopy
  • Optical endoscopy
  • Cancer detection and therapeutic monitoring
  • Miniature and cost-effective optical devices for global health

Selected Recent Publications

S. Voulgarelis, F. Fathi, B.Yu, B. Palkovic, N.A. Chatzizacharias, K.P. Allen, A.G. Stucke, "Hepatic artery flow, inspired oxygen, and hemoglobin determine liver tissue saturation measured with visible diffuse reflectance spectroscopy (vis-DRS) in an in vivo swine model," Pediatr Transplant. 2022 Jan 22:e14230. doi: 10.1111/petr.14230. Epub ahead of print. PMID: 35064720.

S. Voulgarelis, F. Fathi, A.G. Stucke, K.D. Daley, J. Kim, M.A. Zimmerman, J.C. Hong, N. Starkey, K.P. Allen, B. Yu, "Evaluation of visible diffuse reflectance spectroscopy in liver tissue: validation of tissue saturations using extracorporeal circulation," J Biomed Opt. 26(5), 055002 (2021), doi: 10.1117/1.JBO.26.5.055002. PMID: 340215372021.

Tongtong Lu, Julie M. Jorns, Mollie Patton, Renee Fisher, Amanda Emmrich, Todd Doehring, Taly Gilat Schmidt, Dong Hye Ye, Tina Yen, Bing Yu, "Rapid assessment of breast tumor margins using deep ultraviolet fluorescence scanning microscopy," J. Biomed. Opt. 25(12), 126501 (2020), doi: 10.1117/1.JBO.25.12.126501. (Appeared on the cover page of the Journal).

Ullah, R.; Doerfer, K.; Khampang, P.; Fathi, F.; Hong, W.; Kerschner, J.E.; Yu, B., Real-Time Optical Monitoring of Endotracheal Tube DisplacementBiosensors 10(174), 2020.

VK Nagarajan, JM Ward, and B Yu, “Association of Liver Tissue Optical Properties and Thermal Damage,” Lasers in Surgery and Medicine, 09 January 2020.

Benej M, Hong X, Vibhute S, Scott S, Wu J, Graves E, Le QT, Koong AC, Giaccia AJ, Yu B, Chen CS, Papandreou I, Denko NC. Papaverine and its derivatives radiosensitize solid tumors by inhibiting mitochondrial metabolism. Proc Natl Acad Sci U S A. 2018 Oct 16;115(42):10756-10761. doi: 10.1073/pnas.1808945115. Epub 2018 Sep 10. Erratum in: Proc Natl Acad Sci U S A. 2018 Dec 4;115(49):E11561. PMID: 30201710; PMCID: PMC6196495.

Nagarajan VK, Gogineni VR, White SB, Yu B. Real time evaluation of tissue optical properties during thermal ablation of ex vivo liver tissues. Int J Hyperthermia. 2019 Jan 1;35(1):176-182. doi: 10.1080/02656736.2018.1488278. Epub 2018 Aug 21. PMID: 30130988.

P Edwards, C Zhang, B Zhang, X Hong, VK Nagarajan, B Yu, Z Liu, “Smartphone based optical
spectrometer for diffusive reflectance spectroscopic measurement of hemoglobin,” Scientific reports 7 (1), 12224, 2017.

Xiangqian Hong, Vivek K. Nagarajan, Dale H. Mugler and Bing Yu, “Smartphone microendoscopy for high resolution fluorescence imaging,” Journal of Innovative Optical Health Sciences, Vol.09, No. 05, 2016.

Vivek K. Nagarajan and Bing Yu, “Monitoring of tissue optical properties during thermal coagulation of ex vivo tissues,” Lasers Surg. Med., June 1, 2016. doi: 10.1002/lsm.22541.


  • Yu, Bing (Principal Investigator), Kerschner, Joseph; Hong, Wenzhou; “Optical confirmation and monitoring of endotracheal tube position in pediatric patients.” Sponsored by NIH (April 2021–March 2023).
  • Yu, Bing (Principal Investigator), “A Smartphone-based Dual-modality Microendoscope for Cancer Diagnosis.” Sponsored by Ohio Third Frontier Technology Validation and Start-up Fund (May 16, 2016–May 15, 2017).
  • Yu, Bing (Principal Investigator), Denko, Nicholas (co-Investigator), “Longitudinal Assessment of Tumor Hypoxia in vivo Using Near-Infrared Spectroscopy.” Sponsored by NIH, National Cancer Institute (February 11, 2016–January 31, 2019).
  • Yu, Bing (Principal Investigator for the subaward), “A Smartphone-based Dual-modality Microendoscope for Cancer Diagnosis.”  Sponsored by NSF I-Corp through Ohio State University (July 1, 2015–December 31, 2015).
  • Yu, Bing (Principal Investigator), “Noninvasive assessment of the anti-hypoxia effect of metformin in cancer therapy using near-infrared spectroscopy.” Sponsored by the Faculty Summer Fellowship, The University of Akron (May 15, 2015–December 31, 2015).
  • Yu, Bing (Principal Investigator), “Optical spectroscopy for noninvasive evaluation of the efficacy of anti-hypoxia drugs in cancer therapy.” Sponsored by the Firestone Research Initiative Fellowship (May 15, 2014August 31, 2015).

Investigator working in the lab.

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