Measuring photoreceptor mosaic structure and function using advanced noninvasive techniques
Development of image processing and automated analysis tools
Clinical imaging for studying the etiology of retinal disease
Carroll, J. (Principal Investigator); Cooper, RF (Co-PI); “Retinal Contributions to Vision Loss in Albinism.” Sponsored by the National Institutes of Health—National Eye Institute (07/01/2022–06/01/2026). Major Goal: To examine the influence of retinal melanin on visual acuity and the phenotypic spectrum of foveal morphology, characterize disruptions in foveal post-receptoral circuitry in subjects with albinism, and map rod photoreceptor mosaic topography in subjects with albinism.
Cooper, RF (Principal Investigator); “Assessing the Function of Individual Cells in Patients with Inherited Retinal Degenerative Disease.” Sponsored by the Foundation Fighting Blindness (06/30/2020–06/29/2023). Major goal: To enhance and explore the functional signal from individual cells in patients with degenerative diseases.
Buckland E. (Co-Principal Investigator), Carroll J. (Co-Principal Investigator), Cooper RF (Co-Investigator); “Validating Automated Photoreceptor Analytics Software for Degenerative Eye Disease Research and Biopharma Clinical Trials.” Sponsored by National Institutes of Health—National Eye Institute (03/01/2020–02/28/2022). Major goal: To extend the functionality of MOSAIC as a commercial-ready, efficient and user-friendly photoreceptor analysis software for quantifying AO images.
Connor (Principal Investigator), Cooper RF (Co-Principal Investigator); “Assessing Function at a Cellular Scale in Patients with Inherited Retinal Degenerations.” Traditional Pilot Award sponsored by the Clinical and Translational Science Institute of Southeast Wisconsin (08/01/2020–07/31/2021). Major goal: To translate a nascent cellular-scale functional assay to a clinical environment.