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Oct. 19, 2022
Dr. Amit Joshi, Associate Professor and Vice Chair of Research and Clinical Affairs for the Marquette University and Medical College of Wisconsin Joint Department of Biomedical Engineering, serves as project leader for an NIH R01 grant awarded to the Medical College of Wisconsin for investigations into the inherited genes affecting the breast tumor vascular microenvironment. Entitled, “Leveraging Genetic Mapping for personalized targeting of the breast cancer microenvironment,” this project will study the role of germline factors impacting drug and nanoparticle delivery and therapy response of breast cancer.
In a previous project, Dr. Joshi and collaborators defined relevant germline factors and discovered the role of notch-DLL4 expression of 3rd Chromosome on salt sensitive rat as governing tumor proliferation, metastasis, and nanoparticle uptake and therapy response in human tumor xenografts. The current project will leverage the previous discovery to define mechanisms in tumor endothelium that govern drug carrier permeation, retention, and clearance; the impact of co-targeting notch-DLL4 in tumor endothelium with various drug delivery systems; as well as the role of inherited tumor micro-environment targeting for treating distant metastatic disease. When complete, these studies will provide insight to the role of the tumor microenvironment in drug delivery and response to nanoparticle therapies.
This project is a collaboration between various faculty at the Medical College of Wisconsin, including Dr. Anjishnu Banerjee, Associate Professor of Biostatistics; Dr. Benjamin Gantner, Assistant Professor of Endocrinology and Molecular Medicine; Dr. Aron Geurts, Professor of Physiology; Dr. John Langenheim, Department of Pathology and Laboratory Medicine; Dr. Peter LaViolette, Associate Professor of Radiology; and Dr. Hallgeir Rui, Professor and Vice Chair of Research for the Department of Pathology.