Ranjan k. Dash, Ph.D.

Ranjan Dash, Ph.D.Professor and Co-Director of Graduate Studies

(414) 955-4497
Email Dr. Dash
Medical College of Wisconsin
8701 Watertown Plank Road
Milwaukee, WI 53226
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Broad Research Interests

  • Computational Systems Biology & Bioengineering
  • Molecular, Cellular and Integrative Physiology
  • Cardiac and Skeletal Muscular Metabolism

    Specific Research interests

  • Mathematical modeling and computer simulations of complex physiological systems
  • Computational methods and algorithms for data analysis and parameter estimation
  • Microcirculatory oxygen and carbon dioxide transport and exchange and acid-base regulation
  • Physiologically-based pharmacokinetic modeling and drug transport and metabolism
  • Integrated blood-tissue species transport/exchange and cellular energy metabolism
  • Mitochondrial calcium and reactive oxygen species homeostasis in cardiomyocytes
  • Cardiomyocytes electrophysiology, calcium handling, and excitation-contraction coupling
  • Modeling and analysis of large-scale biochemical networks, protein-protein interaction networks, and gene regulatory networks

Professional preparation

  • Postdoc, 2006, Computational Biology, Case Western Reserve University, Cleveland
  • Postdoc, 2003, Computational Biology, University of Washington, Seattle
  • Postdoc, 2000, Computational Biofluid Dynamics, Texas A&M University, College Station
  • Ph.D., 1998, Computational Biofluid Dynamics, Indian Institute of Technology, Delhi, India
  • M.S., 1991, Applied Mathematics, Utkal University, Bhubaneswar, Orissa, India

Selected recent publications

Zhang X, Dash RK#, Jacobs ER, Camara AKS, Clough AV, and Audi SH#. Integrated computational model of the bioenergetics of isolated lung mitochondria. PLoS One 13(6):e0197921, 2018. [# Equal Contributions for Senior Authorships].

Korman B, Dash RK, and Peyton PJ. Can mathematical modeling explain the measured magnitude of the second gas effect? Anesthesiology 128(6): 1075-1083, 2018.

Pannala VR, Camara AKS, and Dash RK. Modeling the detailed kinetics of mitochondrial cytochrome c oxidase: Catalytic mechanism and nitric oxide inhibition. J Appl Physiol, 121: 1196-1207, 2016.

Ranji M, Salehpour F, Motlagh MM, Sepehr R, Heisner JS, Dash RK, and Camara AKS. Optical cryoimaging reveals a heterogeneous distribution of mitochondrial redox states in the ex vivo guinea pig heart and its alteration during ischemia and reperfusion. IEEE J Trans Eng Health Med 4:1800210, 2016.

Blomeyer CA, Bazil JN, Stowe DF, Dash RK, and Camara AKS. Mg2+ differentially regulates two modes of mitochondrial Ca2+ uptake in isolated cardiac mitochondria: Implications for mitochondria Ca2+ sequestration. J Bioenerg Biomemb 48(3):175-178, 2016.

Recent Grants

Dash, Ranjan K. (Principal Investigator), “PPG: Mechanisms of Anesthetic Cardioprotection (Project III: Modeling of Mitochondrial and Cellular Function in Anesthetic Cardioprotection)”, Sponsored by the NIH/NIGMS (March 1, 2015 – February 29, 2020).

Dash, Ranjan K. (Principal Investigator), “Analyzing the Cardiac Power Grid: Adaptive Responses to Fluctuating Local Demand”, Sponsored by the NIH/NHLBI (September 15, 2015 – May 31, 2020).

Dash, Ranjan K. (Co-Principal Investigator); “Systems Biology Based Tools for Modeling Platelet Storage Lesion for Optimal Blood Transfusions”; Sponsored by CFD Research Corporation-US Army (DOD) SBIR Phase II Project (September 26, 2016 – January 25, 2019); Principal Investigator – Andrzej Przekwas, CFD Research Corporation, Huntsville, AL.

Dash, Ranjan K. (Co-Principal Investigator); “Predictive Computational Modeling to Define Antiviral Efficacy”; Sponsored by Research and Education Program (REP) of Advancing Healthier Wisconsin (AHW) Endowment (February 1, 2017 – January 31, 2019); Principal Investigator – Scott Terhune, Microbiology and Immunology, MCW.